YFIBNR MEDIATES CYCLIC DI-GMP DEPENDENT SMALL COLONY VARIANT FORMATION AND PERSISTENCE IN PSEUDOMONAS AERUGINOSA.

YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa.

During long-term cystic fibrosis lung infections, Pseudomonas aeruginosa undergoes genetic adaptation resulting in progressively increased persistence and the generation of adaptive colony morphotypes.This includes small colony variants (SCVs), auto-aggregative, hyper-adherent cells whose appearance correlates with poor lung function and persistenc

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RNA Viral Vectors for Accelerating Plant Synthetic Biology

The tools Patient Room of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants.However, their effective utilization typically requires transgenesis, which is plagued by long timescales and high costs.In this review we explore how transgenesis can be minimized by del

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